Kathy L. Timms, PhD, HCLD

Kathy L. Timms, PhD, HCLD Professor of Obstetrics, Gynecology and Women’s Health

Professor of Animal Sciences

Director, Division of Reproductive and Perinatal Research

Director, MU Assisted Reproduction Laboratories

Education:

PhD - University of Tennessee-Knoxville

Fellowship Training - University of Kentucky-Lexingon

Certification:
High-Complexity Clinical Laboratory Director

Memberships:
Food for the 21^st Century Animal Reproductive Biology Group
The Endometriosis Association
American Association for the Advancement of Science
American Society for Reproductive Medicine (ASRM; formerly AFS)
Reproductive Biology Professional Group
Society for Assisted Reproductive Technology (SART)
Society for the Study of Reproduction
The Association of Professor's of Gynecology and Obstetrics
Society for Gynecologic Investigation
American Association of Bioanalysts
ESHRE Abstract Review Committee

Clinical and Research Interests:

Establishment and maintenance of pregnancy; pathophysiologies of endometriosis, gynecologic malignancies.

Selected Honor-Awards

2003-2007	Associate Editor, Human Reproduction
2004-2007	NIH Study Section Member, NICHD Integrated Clinical Endocrinology and Reproduction Study Section
2003-2004	NIH Study Section Member, NICHD Reproductive Endocrinology
2002	Elected as Charter Member, MU School of Medicine Order of Socrates, an exclusive group awarded for continuing teaching excellence
1994–Present	Elected member of The Society for Gynecologic Investigation
1994–1996	Board of Directors, Society for Assisted Reproductive Technology Executive Council, American Society for Reproductive Medicine
1992–1993	National Institutes of Health James A. Shannon Award Endometriosis-associated secretary proteins
1977–Present	Phi Kappa Phi National Honor Society

Selected Publications:

Sharpe (Timms) KL, Zimmer RL, Griffin WT, Penney LL. Polypeptides synthesized and released by human endometriosis tissue differ from those of the uterine endometrium in culture. Fertil Steril 1993; 60(5):839-51.

Sharpe-Timms KL, Piva M, Ricke EA, Surewicz K, Zhang YL, Zimmer RL. Endometriotic lesions synthesize and secrete a haptoglobin-like protein. Biol Reprod 1998; 58:988-94.

Sharpe-Timms KL, Zimmer RL, Jolliff WJ, Wright JA, Nothnick WB, Curry TE. Gonadotropin-releasing hormone agonist (GnRHa) therapy alters activity of plasminogen activators (PA), matrix metalloproteinases (MMP) and of their inhibitors (PAI and MMPI) in rat models for adhesion formation and endometriosis: potential GnRHa-regulated mechanisms reducing adhesion formation. Fertil Steril 1998; 69(5):916-23.

Sharpe-Timms KL, Keisler LW, McIntush EW, Keisler DH. Tissue inhibitor of metalloproteinase-1 (TIMP-1) concentrations are attenuated in peritoneal fluid and sera of women with endometriosis and restored in sera by gonadotropin-releasing hormone agonist (GnRHa) therapy. Fertil Steril 1998; 69(6): 1128-34.

Piva M, Sharpe-Timms KL. Peritoneal endometriotic lesions differentially express a haptoglobin-like gene. Molecular Human Reprod 1999; 5: (1):71-78.

Sharpe-Timms KL, Ricke EA, Piva M, Horowitz GM. Differential in vivo expression and localization of endometriosis protein-I (ENDO-I), a haptoglobin homologue, in endometrium and endometriotic lesions. Human Reproduction, 2000; 15(10):2180-5.

Piva M, Horowitz GM, Sharpe-Timms KL. Interleukin-6 differentially stimulates haptoglobin production by peritoneal and endometriotic cells in vitro: a model for endometrium-peritoneum interaction in endometriosis. J Clin Endocrin Metab 2001; 86:2553-61.

Sharpe-Timms KL, Zimmer RL, Ricke EA, Piva MA, Horowitz GM. Endometriotic haptoglobin binds peritoneal macrophages and alters their function in endometriosis. Fertil Steril; 2002; 78:810-819.

Piva MA, Moreno I, Sharpe-Timms KL. Glycosylation and over-expression of endometriosis-associated peritoneal haptoglobin. Glycoconj J 2003; 19(1):33-41.

Sharpe-Timms, KL. Haptoglobin expression by shed endometrial tissue fragments found in peritoneal fluid. Fertil Steril 2005; 84(1):22-30:35-7.

Sharpe-Timms, KL. Defining endometrial cells: the need for improved identification at ectopic sites and characterization in eutopic sites for developing novel methods of management for endometriosis. Fertil Steril 2005; 84(1):35-7; discussion 38-9:22-30.

Barrier BF, Kendall BS, Sharpe-Timms KL, Kost ER. Characterization of human leukocyte antigen-G (HLA-G) expression in endometrial adenocarcinoma. Gynecol Oncol. 2006 Mar 9; [Epub ahead of print]

Barrier BF, Kendall BS, Ryan CE, Sharpe-Timms KL. HLA-G is expressed by the glandular epithelium of peritoneal endometriosis but not in eutopic endometrium. Hum Reprod. 2006 Apr; 21(4):864-9. Epub 2005 Nov 25.

Hegedűs B, Marga F, Jakab K, Sharpe-Timms KL, Forgács G. The interplay of cell-cell and cell-matrix interactions in the invasive properties of brain tumors. Biophysical J 2006; 91(7): 1-9.

Cameo P, Szmidt M, Strakova Z, Mavrogianis P, Sharpe-Timms KL, Fazleabas AT. Decidualization regulates the expression of the endometrial chorionic gonadotrophin receptor in the primate. Biol Reprod. 2006 Jul 12; [Epub ahead of print]