Dennis B. Lubahn, PhD

Associate Professor, Biochemistry & Child Health

Education:

PhD - Duke University, Durham, NC

Postdoctoral Training - University of North Carolina, Chapel Hill

Research Interests:

Phytoestrogen action in human disease, ERRbeta isoforms in breast cancer, phytoestrogens in preventing and treating colon cancer.

Selected Publications:

Lubahn DB , Joseph DR, Sullivan PM, Willard HF, French FS, Wilson EM. Cloning of human androgen receptor cDNA & localization to the X chromosome. Science 240:327-30, 1988.

Lubahn DB, Joseph DR, Sar M, Tan J, Higgs HN, Larson RE, French FS, Wilson EM. The human androgen receptor: complementary deoxyribonucleic acid cloning, sequence analysis and gene expression in prostate. Mol Endocrinol 1988;2:1265-75.

Rennie P, Bowden J, Freeman S, Bruchovsky N, Cheng H, Lubahn D, Wilson E, French F, Main L. Cortisol alters gene expression during involution of the rat ventral prostate. Mol Endocrinol 1989;3:703-8.

Lubahn DB, Moyer JS, Golding TS, Couse JF, Korach KS, Smithies O. Alteration of reproductive function but not prenatal sexual development after insertional disruption of the mouse estrogen receptor gene. Proc Natl Acad Sci USA 1993;90:11162-6.

Iafrati M, Karas R, Aronovitz M, Kim S, Sullivan T Jr, Lubahn D, O'Donnell T Jr, Korach K, Mendelsohn M. Estrogen inhibits the vascular injury response in estrogen receptor alpha-deficient mice. Nat Med 1997;3:545-8.

Cooke P, Buchanan D, Young P, Setiawan T, Brody J, Korach K, Taylor J, Lubahn D, Cunha G. Stromal estrogen receptors mediate mitogenic effects of estradiol on uterine epithelium Proc Natl Acad Sci USA 1997;94:6535-40.

Huang T, Laux D, Hamlin B, Tran P, Tran H, Lubahn D. Identification of DNA methylation markers for human breast carcinomas using the methylation-sensitive restriction fingerprinting technique. Cancer Res 1997;57:1030-4.

Hess RA, Bunick D, Korach KS, Bahr J, Lee K-H, Taylor JA, Lubahn DB. Estrogen regulates fluid reabsorption in the head of the epididymis. Nature 1997;390:509-12.

Das S, Taylor J, Korach K, Paria B, Dey S, Lubahn D. Estrogenic responses in estrogen receptor-alpha deficient mice reveal a novel estrogen-signaling pathway. Proc Nat Acad Sci 1997;94:12786-91.

Cooke PS, Buchanan DL, Lubahn DB, Cunha GR. Mechanism of estrogen action—lessons from the estrogen receptor-alpha knockout mouse. Biol Reprod 1998;59:470-5.

Smithson G, Couse JF, Lubahn DB, Korach KS, Kincade PW. The role of estrogen receptors and androgen receptors in sex steroid regulation of B lymphopoiesis. J Immunol 1998;161:27-34.

Ghosh D, Taylor JA, Green JA, Lubahn DB. Methoxychlor stimulates estrogen-responsive mRNAs in mouse uterus through a non-estrogen receptor- a and non-estrogen receptor- b mechanism. Endocrinol 1999;140:3526-33.

Schatten H, Wiedemeier AM, Taylor M, Lubahn DB, Greenberg NM, Besch-Williford C, Rosenfeld CS, Day JK, Ripple M. Centrosome-centriole abnormalities are markers for abnormal cell divisions and cancer in the transgenic adenocarcinoma mouse prostate (TRAMP) model. Biol Cell 2000;92:331-40.

Day J, Besch-Williford C, McMann T, Hufford M, Lubahn D, MacDonald R. Dietary genistein increased DMBA-induced mammary adenocarcinoma in wild-type, but not ER alpha KO, mice. Nutr Cancer 2001;39:226-32.

Day J, Bauer A, desBordes C, Zhuang Y, Kim B-E, Newton L, Nehra V, Forsee K, MacDonald R, Besch-Williford C, Huang T-M, Lubahn D. Genistein alters methylation patterns in mice. J Nut 2002;132:2419-23.

Ansell PJ, Espinosa-Nicholas C, Curran EM, Judy BM, Philips BJ, Hannink M, Lubahn DB. In vitro and in vivo regulation of antioxidant response element-dependent gene expression by estrogens. Endocrinology 2004;145(1):311-7.

Guo JY, Li X, Browning JD Jr, Rottinghaus GE, Lubahn DB, Constantinou A, Bennink M, MacDonald RS. Dietary soy isoflavones and estrone protect ovariectomized ERαKO and wild-type mice from carcinogen-induced colon cancer. J Nutr 2004;134:179-82.

Philips BJ, Ansell PJ, Newton LG, Harada N, Honda S-I, Ganjam VK, Rottinghaus GE, Welshons WV, Lubahn DB. Estrogen receptor-independent catechol estrogen binding activity: protein binding studies in wild-type, estrogen receptor - a KO & aromatase KO mice tissues. Biochemistry. 43(21):6698-708. 2004.

Shenouda NS , Zhou C, Browning JD, Ansell PJ, Sakla MS, Lubahn DB, MacDonald RS. Phytoestrogens in Common Herbs Regulate Prostate Cancer Cell Growth in Vitro. Nutrition and Cancer 2004; 49(2), 200-208.

Ansell PJ, Lo S-C, Newton LG, Espinosa-Nicholas C, Zhang D, Liu J, Hannink M, Lubahn DB Repression of Cancer Protective Genes by 17 b -estradiol: Ligand-Dependent Interaction Between Human Nrf2 and Estrogen Receptor a . Mol Cell Endo in press 2005.