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John R. Lever, PhD

Associate Professor of Radiology

Education:

PhD - North Carolina State University, Raleigh

Postdoctoral Training - The Johns Hopkins University, Baltimore

Research Interests:

Opioid receptors, Dopamine transporters, Molecular imaging.

Selected Publications:

Lever JR, Zou M-F, Parnas ML, Duval RA, Wirtz SE, Justice JB, Vaughan RA, Newman AH: Radioiodinated azide and isothiocyanate derivatives of cocaine for irreversible labeling of dopamine transporters: synthesis and covalent binding studies. Bioconjugate Chem 16:644-649, 2005.

Duval RA, Allmon RL, Gustafson JL, Carmack TL, Watkinson LD, Lever JR: An indium-labeled DO3A conjugate of naltrindole with high affinity and selectivity for delta opioid receptors: synthesis, binding studies and biodistribution . J Label Compd Radiopharm 48:S8, 2005.

Cao J, Lever JR, Kopajtic T, Katz JL, Pham AT, Holmes ML, Justice JB, Newman AH: Novel azido and isothiocyanato analogues of [3-(4-phenylalkyl piperazin-1-yl)propyl]bis(4-fluorophenyl)amines as potential irreversible ligands for the dopamine transporter. J Med Chem 47:6128-6136, 2004.

Lever JR, Ilgìn N, Musachio JL, Scheffel U, Finley PA, Flesher JE, Natarajan TK, Wagner HN Jr., Frost, JJ: Autoradiographic and SPECT imaging of cerebral opioid receptors with an iodine-123 labeled analogue of diprenorphine. Synapse 29: 172-182, 1998.