Kattesh V. Katti, PhD

Kattesh V. Katti, PhD Professor of Radiology & Physics

Senior Research Scientist MU Research Reactor

Education:

Ph.D 1984, Indian Institute of Science, Bangalore, India

M.S.Ed. 1979, Regional College of Education, Mysore, India

B.S.(Chemistry)1977, Karnatak University, India

Research Interests:

Nanoscience and Nanotechnology in Nanomedicine, Metals/Organomatallics In the Development of Cancer Diagnostic and Therapeutic Agents, Biomedical Optical Imaging, New Approaches to Cancer Therapy, New Biomaterials for use in Surgical and Non-surgical Wound Healing applications, Fundamental Aspects of Structure of Water and Water-Alcohol Binary Mixtures.

Selected Publications:

N. Pillarsetty, K. Raghuraman, C. Barnes, K. V. Katti, Design, Synthesis and Chemistry of Sterically Non-Demanding Primary Bis-Phosphines, J. Am. Chem. Soc, 127, 331-336, 2005.

K. Raghuraman, N. Pillarsetty, K. R. Prabhu, K. K. Katti and K. V. Katti, Unprecedented rhodium-mediated catalytic transfer hydrogenation of a phosphonate functionalized olefin in ecofriendly media, Inorganica Chimica Acta, 357, 2933-2938, 2004.

K. V. Katti, N. Pillarsetty, K. Raghuraman, New Vistas in Chemistry and Applications of Primary Phosphines, Topics in Current Chemistry, 229, 121-141, 2003.

K. Raghuraman, K. K. Katti, L. J. Barbour, N. Pillarsetty, C. L. Barnes, K. V. Katti, Characterization of Supramolecular (H₂O)₁₈Water Morphology and Water-Methanol (H₂O)₁₅(CH₃OH)₃ Clusters in a Novel Phosphorus Functionalized Trimeric Amino Acid Host. J. Am. Chem. Soc., 125(23), 6955-6961, 2003.

N. Pillarsetty, K. K. Katti, Hoffman, T. J., Volkert, W. A., Katti, K. V., Kamei, H., Koide, T. In vitro and in vivo antitumor properties of Tetrakis((trishydroxymethyl)phosphine)gold(I) chloride. J. Med. Chem., 46(7), 1130-1132, 2003

K. K. Kothari, K. Raghuraman, N. Pillarsetty, T. J. Hoffman, N. K.Owen, K. V. Katti, W. A. Volkert, Syntheses, in vitro and in vivo characterization of a^99mTc-(I)-tricarbonyl-benzylamino-dihydroxymethyl phosphine (NP₂) chelate. App. Rad. Iso., 58(5), 543-549, 2003

K. K. Kothari, N. K. Pillarsetty, K. V. Katti, Volkert, W. A. Characterization of complexation reactions of mono- and bidentate-hydroxymethyl phosphine ligands with the organometallic ^99mTc(I)(OH₂)₃ (CO)₃⁺SYNTHON. Radiochim. Acta 91, 53-57, 2003.

K. Raghuraman, N. Pillarsetty, W. A. Volkert, C. Barnes, S.Jurisson and K. V. Katti. Exceptional Kinetic Propensity of Hydroxymethyl Phosphanes toward Rh(III) Stabilization in Water. J. Am. Chem. Soc., 124, 7276-7277, 2002.

K. V. Katti, K. Raghuraman, N. Pillarsetty, S. R. Karra, R. J. Gulotty, M. A. Chartier and C. A. Lanhoff. First examples of Azaphosphanes as Efficient Electron Donors in the Chemical Architecture of Thermally Stable New Nonlinear Optical Materials. Chem. Mat., 14, 2436-2438, 2002.

K. K. Kothari, H. Gali, K. R. Prabhu, N. Pillarsetty, N. K. Owen, K. V. Katti, T. J. Hoffman and W. A. Volkert. Synthesis and Characterization of ^99mTc and ¹⁸⁸Re- complexes with a diamido-dihydroxymethylenephosphine-based bifunctional chelating agent. (N₂P₂-BFCA) Nucl. Med. Biol., 29, 83-89, 2002.

H. Gali, T. J. Hoffman, G. L. Sieckman, N. K. Owen, K. V. Katti, and W. A. Volkert. Synthesis, Characterization, and Labeling with ^99mTc/¹⁸⁸Re of Peptide Conjugates Containing a Dithia-bisphosphine Chelating Agent, Bioconjugate Chem., 12(3), 354-363, 2001.

K. R. Prabhu, N. Pillarsetty, H. Gali and K. V. Katti. Unprecedented No Solvent Mediated Selective Bisaminolysis: Aminopropyl Phosphine as a Novel Synthon for Air Stable Bisamido-Bisprimaryphosphines. J. Am. Chem. Soc., 122, 1554-1555, 2000.

H. Gali, K. R. Prabhu, S. R. Karra and K. V. Katti. Facile Ring Opening Reactions of Phthalimides as a New Strategy to Synthesize Amide Functionalized Phosphonates, Primary Phosphines and Bisphosphines. J. Org. Chem., 65, 676-680, 2000.

H. Gali, S. R. Karra, V. S. Reddy, K. V. Katti, Design and Development of the First Peptide-Chelating Bisphosphine Bioconjugate via a Novel Carboxylate Functionalized Phsophorus(III) Hydride. Angew. Chem. Int. Ed. Engl., 38, 2020-2023, 1999.

D. E. Berning, K. V. Katti, C. L. Barnes, W. A. Volkert, Chemical and biomedical motifs of the reactions of hydroxymethyl phosphines with amines, amino acids and model peptides. J. Am. Chem. Soc., 121, 1658-1664, 1999.

K. V. Katti, H. Gali, D. E. Berning, C. J. Smith, Design and development of functionalized water-soluble phosphines: Catalytic and biomedical implications. Acc. Chem. Res. 32(1), 9-17, 1999.

Recent Discoveries

Dr. Katti’s discovery on Nanoparticles production was quoted on the front page of NANO BIOTECH NEWS (Vol. 2; No 48; December 8 2004 http://www.nhionline.net/products/nanobiotechnews/nbn12804week.pdf)“240 times faster than previous methods; University of Missouri-Columbia researchers make gold, silver nanoparticles in 5-10 minutes”

Dr. Katti’s Nanoscience work was cited in Innovations Report of Germany (http://www.innovations-report.com/html/reports/life_sciences/report-36440.html) as “Nanoparticles to Aid Medical Diagnosis, Therapy”

Dr. Katti’s work was cited in NANO TECHNOLOGY NOW: “MU Researchers Produce Nanoparticles to Aid Medical Diagnosis, Therapy in Fraction of Previous Time” (http://www.nanotech-now.com/news.cgi?story_id=06721)

Dr. Katti’s Nanoscience discovery was cited in: Nano Tsunami: http://www.voyle.net/Nano%20Medicine/Medicine%202004-0058.htm

Dr. Katti’s discovery was cited in one of the major vitamin health sites in the U.S. Dr. Katti’s work do develop a new drug for Wilson’s Disease is featured. http://newvitality.com/Articles.aspx

Dr. Katti’s discovery on the development of a new drug for treating Wilson’s disease was cited in: http://atmizzou.missouri.edu/novdec04/LiverDrug. This discovery was covered in National/International news media.