Charles William Caldwell, MD, PhD

Director, Ellis Fischel Cancer Center

CRC Missouri Chair in Cancer Research

Professor of Pathology and Anatomical Sciences

Education:

MD - University of Missouri - Columbia School of Medicine

PhD - University of Missouri - Columbia School of Medicine

Fellowship Training - National Cancer Institute

Residencies -University of Missouri - Columbia School of Medicine

Clinical Interests:

Hematopathology, hematology

Research Interests:

Epigenetic alterations in human lymphomas and leukemias.

Selected Publications:

Shi H, Yan PS, Chen C-M, Rahmatpanah F, Lofton-Day C, Caldwell CW, Huang TH-M. ECIST (Expressed CpG Island Sequence Tag) microarrays for dual screening of DNA hypermethylation and gene silencing in cancer cells. Cancer Res 2002;62:3214-3220.

Shi H , Maier S, Nimmrich I, Yan PS, Caldwell CW , Olek A, Huang TH-M. Oligonucleotide-based microarray for DNA methylation analysis: principles and applications. Journal of Cellular Biochem 2003;88:138-143.

Yang H, Chen CM, Yan P, Huang TH-M, Shi H, Burger M, Nimmrich I, Maier S, Berlin K, Caldwell CW: The androgen receptor gene is preferentially hypermethylated in follicular non-Hodgkin’s lymphomas. Clin Cancer Res 9:4043-4042, 2003.

Chen CM, Chen HL, Shi H, Caldwell CW, Brock G, Yan PS, Huang TH-M. Methylation target array for rapid analysis of promoter hypermethylation in multiple tissue genomes Am J Pathol 163:37-45, 2003.

Guo J, Burger M, Nimmrich I, Maier S, Becker E, Genc B, Duff D, Rahmatpanah F, Chitma-Matsiga R, Shi H, Berlin K, Huang TH-M, Maier, Caldwell CW. Differential DNA methylation of gene promoters in small B-cell lymphomas. Am J Clin Pathol (in press)

Zhang LN, Karp P, Gerard CJ, Pastor E, Laux D, Munson K, Yan Z, Liu X, Godwin S, Thomas C, Zabner, J, Shi, H, Caldwell CW, Peluso, R, Carter B, and Engelhardt JF: Dual Therapeutic Utility of Proteasome Modulating Agents for Pharmaco-Gene Therapy of the Cystic Fibrosis Airway. Mol Therapy 10:990-1002, 2004.