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Stephen Alexander, PhD

Professor, Division of Biological Sciences

Education:

PhD - Brandeis University, Waltham, MA

Postdoctoral Training - Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA

Research Interests:

Molecular mechanisms of resistance to anticancer drugs; role of sphingolipids in drug resistance and tumor growth.

Selected Publications:

Min, J., Stegner, A.L., Alexander, H., and Alexander S. (2004). Overexpression of sphingosine-1-phosphate lyase or inhibition of sphingosine kinase in Dictyostelium discoideum results in a selective increase in sensitivity to platinum-based chemotherapy drugs. Eukaryotic Cell. 3: 795-805.

Kumar, A., Wessels, D., Daniels, K.J., Alexander, H., Alexander, S., and Soll, D.R. (2004) Sphingosine-1-phosphate plays a role in the suppression of lateral pseudopod formation during Dictyostelium discoideum cell migration and chemotaxis. Cell Motility and the Cytoskeleton. 59: 227-241.

Alexander, H., Stegner, A.L., Wagner-Mann, C., Du Bois, G.C., Alexander, S., and Sauter, E.R. (2004). Proteomic analysis to identify breast cancer biomarkers in nipples aspirate fluid. Clinical Cancer Research. 10: 7500-7510.

Min, J., Traynor, D., Stegner, A.L., Zhang, L., Hanigan, M.H., Alexander, H., and Alexander, S. (2005) Sphingosine kinase regulates the sensitivity of Dictyostelium discoideum cells to the anticancer drug cisplatin. Eukaryotic Cell. 4: 178-189.

Min, J., Van Veldhoven, P.P., Zhang, L., Hanigan, M.H., Alexander, H., and Alexander, S. (2005) Sphingosine-1-phosphate lyase regulates sensitivity of human cells to select chemotherapy drugs in a p38-dependent manner. Mol. Cancer Res. 3: 287-296.